Blood purification - Double Filtration Plasmapheresis (DFPP)

A treatment that cleanses the blood in your veins.

Advanced Blood Cleaning and Detoxification

What is DFPP Therapy

DFPP stands for “Double filtration plasmapheresis”.

DFPP is a state-of-the-art technology designed to filter unwanted substances from the blood based on Precision Medicine. This advanced method is specifically designed to efficiently purify blood to help improve patient health and well-being.

Through this technology, which selectively removes toxic substances and metabolites in blood plasma, you just receives your own “cleaned” blood back. Now, you can prevent or treat diseases that can occur due to aging.

Double filtration plasmapheresis recovery Effect(Blood purification)
Retrieved material of DFPP

Substances in the blood that can be removed:

  • LDL Cholesterol
  • Corona Virus, SARS
  • HIV(Human Immunodeficiency Virus)
  • IgM(Immunoglobulin M)
  • Hepatitis C Virus
  • Hepatitis B Virus
  • Bad blood clot
  • Bad Viruses
Experience of DFPP therapy

Safety and effectiveness of DFPP

DFPP is a recognized treatment option for a number of conditions and we have been using it in our center for over ten years.

Benefits of DFPP
  • Clean the blood
  • Remove pathological aging factors
  • improvement of physical condition
  • Prevention of vascular diseases
  • CRP decreased

Remove impurities from your body for healing

The total length of blood vessels in the human body is 125,000 km, which is enough to circle the Earth three times. If bad substances such as cholesterol, neutral fat, oxygen radicals, and heavy metals increase in the blood vessels, it reduces the ability to excrete waste products and becomes the main cause of chronic diseases and aging. DFPP is a treatment that purifies and purifies your blood.

What are the benefits of DFPP Therapy?

To prevent and treat the following diseases:
Hyper-LDL- cholesterolemia (Triglyceridemia)
Cardiovascular disease
Vascular dementia
Myocardial infarction, Stroke
dfpp-prevention-diabetes
Improving health conditions as follows:
dfpp effect for ribido increased
dfpp effect for removal fatigue
dfpp effect for removal numbness
dfpp effect for Allergy and Free Raidcal
dfpp effect for skin brightening
Our programs for the best treatment

Indications for DFPP

• Metabolic disorders
• Blood Disorders
• Hyper-LDL-cholesterolemia (Hypertriglyceridemia)
• Myasthenia gravis
• Auto-immune Disorders(Rheumatism, Multiple Myeloma, SLE)
• Immune System Modulation
• Acute liver failure
• Neurological disorders (After completing the procedures, neurological improvement was recorded in 80% of the patients.*)
• Chronic Kidney Disease, Pancreatitis
• Refsum’s disease
• Hyperviscosity syndrome (Waldenström’s disease, cryoglobulinemia)
• Kawasaki disease

If you have a serious condition, you can use your country’s health insurance system. However, it is an optional treatment for initial or preventive purposes. Preventive management of the disease at an early stage is required to prevent complications and be effective. CellUp Med doctors first perform DFPP depending on the patient’s health status to achieve synergy in stem cell treatment. Contact our team doctor for more details.

Treatment proven effective by research

Effectiveness evidence

A survey of ten chronic high-risk patients in Germany with severe hypertriglyceridemia demonstrated the efficacy and tolerability of long-term DFPP. The absolute number of acute pancreatitis and cardiovascular complications was significantly reduced by 77%.

Hypertriglyceride-associated events (acute pancreatitis, progression of cardiovascular complications) in the observation period before and with DFPP; n=10).
Our programs for the best treatment

Flow of treatment

DFPP uses a membrane-type plasma separator to separate plasma from blood and passes it through a secondary filtration membrane to remove pathogen-related substances present in the plasma. Substances that cannot pass through the secondary filtration membrane are removed, and those that can pass are returned to the body.

An aqueous albumin solution is replenished to prevent hypoalbuminemia (a condition in which albumin, a protein present in the blood, is lower than normal).

Blood purification DFPP Process step 1

STEP 1

Treatment time is approximately 2-3 hours. A nurse and a clinical engineer will be stationed in your room at all times. You can receive the treatment with peace of mind.

Blood purification DFPP Process step 2

STEP 2

Insert one needle in each arm. The needle used is about 2 diameters thicker than the needle used to administer the intravenous drip. Blood is removed from one arm (suction of blood) and blood is pumped from the other arm (blood is returned).

Blood purification DFPP Process step 3

STEP 3

Purifies the blood. The amount of blood circulating during blood purification is approximately 4,000 to 5,000 ml. The amount of plasma to be purified is planned to be 1,500 ml for men and 1,200 to 1,300 ml for women. This condition varies depending on age and weight.

Blood purification DFPP Process step 4

STEP 4

stops the bleeding Once the bleeding has sufficiently stopped, you can go home immediately. Please take sufficient nutrition and fluids after treatment. You may take a bath after your treatment, but please refrain from strenuous exercise.

FAQ about DFPP

Dialysis is a treatment for people with kidney failure, but at our hospital, it is effective in preventing arteriosclerosis, myocardial infarction, and cerebral infarction by removing triglycerides and LDL (bad cholesterol).

Blood, which accounts for approximately 8% of a human’s body weight, will be used to prepare 1,500 ml of blood for men and 1,200 to 1,300 ml for women. This condition varies depending on age and weight.

In rare cases, a drop in blood pressure and discomfort may occur. 

There have been no reports of severe side effects from this treatment.

Please try it for about 2-3 hours.
Since needles are inserted into both arms, you will generally not be able to move during the treatment, but you will be able to watch movies on Netflix/TV during the treatment.

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History of Plasmatherapeutic

Plasmatherapeutic procedures have been performed for the first time at the beginning of the 20th century and their application becomes really active during the 70’s all over the world.

The first plasmapheresis was performed in Russia in 1913 by Yurevitch and Rosenberg to demonstrate the concept of “ … washing the blood outside the body …”. It consisted in extracting a portion of the rabbits blood which was then centrifuged to separate the red blood cells. These were then mixed to normal saline which was heated before being reinjected to the rabbits.

However the term plasmapheresis was defined by Pr John Abel in USA in 1914, combining two terms :
• Plasma: liquid part of the blood
• Aphaeresis: In Greek “removal”

Thus, plasmapheresis was totally defined as a method of removal of plasma from an organism.
Unfortunately the First World War began which stopped the experiments and this technical approach was forgotten for a few decades.

In 1944, the Swedish physician Jan G. Waldenström described a case of Macroglobulinemia with symptoms of increased blood viscosity.

In 1955, he performed effective plasmapheresis procedures on a patient with macroglobulinemia and noted an effective reduction of macroglobulin in the blood.

In 1963, several procedures were successfully performed on patients with Waldenström illness (Macroglobulinemia with high blood viscosity) which can be considered as the start of a regular application of plasmapheresis to a human disease.

Plasmapheresis is regularly performed in many countries since the 70’s with approximately 1000 procedures in England, 6200 in France and later in the 80’s with 50 000 procedures per year in the USA.

Today the term plasmapheresis includes different techniques (filtration or adsorption on plasma), which remove not all but only specific elements contained in the plasma, and altogether allow to treat a large number of diseases.

※ Reference :

  • J-STAGE. ANTI-AGING MEDICINE. Volume 6 (2009) Issue 5 Pages 32-40.
  • Informed Company in Swiss
  • Double Filtration Plasmapheresis Treatment of Refractory Multiple Sclerosis Relapsed on Fingolimod: A Case Report
  • The Journal of Rheumatology April 2012, jrheum.110978
  • Grupp et al., 2020
  • Acta Clin Croat. 2019 Dec; 58(4): 621–626.

※ Notice : The availability of each medical program may vary depending on the selected country depending on medical laws.

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